Leukemic - Like Membrane Properties Acquired by B Lymphocytes
نویسندگان
چکیده
Human peripheral blood lymphocytes can be phenotypically identified by the presence of one or both of two proteins. 225,000-dalton macromolecular insoluble cold globulin (225-MICG) and 185,000-dalton MICG (185-MICG). T cells synthesize and insert into their plasma membrane 225MICG. null cells 1 85-MICG. and B cells both 225 and 1 85-MICG. In contrast, the monoclonal B cells of chronic lymphocytic leukemia are characterized by the presence of 225-MICG and the absence of 1 85-MICG. We have recently found it possible to chemically deplete 1 85-MICG from viable normal B cells by treating them with diisopropylfluorophosphate (DFP). thus making normal B cells phenotypically resemble leukemic cells. In the present report we
منابع مشابه
Leukemic-like membrane properties acquired by B lymphocytes when depleted of 185,000-dalton macromolecular insoluble cold globulin.
Human peripheral blood lymphocytes can be phenotypically identified by the presence of one or both of two proteins, 225,000-dalton macromolecular insoluble cold globulin (225-MICG) and 185,000-dalton MICG (185-MICG). T cells synthesize and insert into their plasma membrane 225-MICG, null cells 185-MICG, and B cells both 225 and 185-MICG. In contrast, the monoclonal B cells of chronic lymphocyti...
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